The Influence of Dental Implants on the Circadian Clock and the Role of Melatonin in the Oral Cavity

The circadian rhythm regulates many physiological human health and disease processes. central clock is located in the suprachiasmatic nucleus hypothalamus controls a whole range of genes. During bone remodeling, gene expression was observed osteoblasts osteoclasts. Moreover, genes are an essential part network osseointegration titanium implants. Namely, biomaterials significantly affect oral cavity thus regulate establishment osseointegration. In addition, vitamin D has potential practical implications for patients with dental implants because sufficient levels before surgery improve process. Also, hormone melatonin, whose production depending on rhythm, affects homeostasis. Therefore, melatonin formation could serve as regenerative agent by increasing process This review highlights impact